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ea0090p186 | Reproductive and Developmental Endocrinology | ECE2023

Gene expression differences between small and large follicles

Baschieri Lara , Cimadomo Danilo , Davolio Federica , Sperduti Samantha , Mascolo Elisa , Paradiso Elia , Lazzaretti Clara , Perri Carmela , Roy Neena , Innocenti Federica , Albricci Laura , Rienzi Laura , Vaiarelli Alberto , Maria Ubaldi Filippo , Simoni Manuela , Casarini Livio

In assisted reproduction, poor ovarian response to controlled ovarian stimulation (COS) leads to poor oocyte yield and depends on the genetic background. We compared the expression of key-genes, coding proteins regulating follicular development, between small (<10 mm) and large ovarian follicles (>16 mm), assuming the size as a hallmark of follicle maturation and oocyte fate. Twenty-two patients undergoing COS were enrolled in a fertility clinics. Granulosa cells and folli...